nicotinic acid

nicotinic acid
= niacin
a B vitamin. Nicotinic acid is a derivative of pyridine and is interchangeable with its amide, nicotinamide. Both forms of the vitamin are equally active. Nicotinamide is a component of the coenzymes NAD (nicotinamide adenine dinucleotide) and NADP, its phosphate. Nicotinic acid is required in the diet but can also be formed in small amounts in the body from the essential amino acid tryptophan. A deficiency of the vitamin leads to pellagra. Good sources of nicotinic acid are meat, yeast extracts, and pulses. The adult recommended intake is 18 mg equivalent per day (1 mg equivalent is equal to 1 mg of available nicotinic acid or 60 mg tryptophan).
Nicotinic acid is used clinically as a lipid-lowering drug. It is effective in reducing levels of triglycerides and low-density lipoproteins in the blood when these are not adequately controlled by statins alone. It is administered by mouth; side-effects include diarrhoea, nausea and vomiting, abdominal pain, and rash.
Trade names:
Niaspan.

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  • nicotinic acid — ic o*tin ic ac id, n. (Chem.) An organic acid ({C6H5NO2}), a carboxylated derivative of pyridine, obtained by the oxidation of nicotine; called also {niacin} and {antipellagra vitamin}, and {vitamin B5}. Chemically it is 3 pyridinecarboxylic acid …   The Collaborative International Dictionary of English

  • nicotinic acid — nicotinic acid. См. никотиновая кислота. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

  • nicotinic acid — ► NOUN Biochemistry ▪ a vitamin of the B complex which occurs in milk, wheat germ, meat, and other foods …   English terms dictionary

  • nicotinic acid — n. a white, odorless, crystalline substance, C6H5NO, found in protein foods or prepared synthetically: it is a member of the vitamin B complex and is used in the treatment of pellagra …   English World dictionary

  • Nicotinic acid — Deficiency of nicotinic acid (also known as niacin), one of the B complex vitamins, causes pellagra. Pellagra was known as the disease of the four D s dermatitis, diarrhea, dementia and death. The disease is specifically characterized by:… …   Medical dictionary

  • nicotinic acid — niacin iacin n. A B vitamin (vitamin B5) essential for the normal function of the nervous system and the gastrointestinal tract. Called also {nicotinic acid} and {antipellagra vitamin}. Chemical formula {C6H5NO2}, chemically it is 3… …   The Collaborative International Dictionary of English

  • nicotinic acid — nikotino rūgštis statusas T sritis chemija formulė NC₅H₄COOH atitikmenys: angl. niacin; nicotinic acid rus. ниацин; никотиновая кислота ryšiai: sinonimas – 3 piridinkarboksirūgštis sinonimas – niacinas sinonimas – vitaminas PP …   Chemijos terminų aiškinamasis žodynas

  • Nicotinic acid adenine dinucleotide phosphate — Identifiers CAS number 5502 96 5 …   Wikipedia

  • nicotinic acid — (= pyridine 3 carboxylic acid) A precursor of NAD, that is a product of the oxidation of nicotine …   Dictionary of molecular biology

  • nicotinic acid — Biochem. a crystalline acid, C6H5NO2, that is a component of the vitamin B complex, found in fresh meat, yeast, etc., produced by the oxidation of nicotine, and used in the prevention and treatment of pellagra. Also called niacin, vitamin B3.… …   Universalium

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